Product ID:RIFAMPICIN CRYSTALLINE, R3501
MSDS Date:01/01/1999
FSC:6505
NIIN:00N092680
Status Code:A
MSDS Number: CJVQC

Emergency Phone: 314-771-5765

Info Phone: 314-771-5765

Cage: 21076

Telephone: 314-771-5765

Cage: 21076

RIFAMPICIN CRYSTALLINE

CAS: 13292-46-1

RTECS: VJ7000000

LD50 LC50 Mixture:LD50: (ORAL,RAT) 1570 MG/KG
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:ACUTE: HARMFUL IF SWALLOWED, INHALED,
OR ABSORBED THROUGH SKIN. CAUSES EYE AND SKIN IRRITATION. MATERIAL
IS IRRITATING TO MUCOUS MEMRANES AND UPPER RESPIRATORY TRACT.
EXPOSURE CAN CAUSE ANOREXIA, NAUS EA, VOMITING AND INFLUENZA-LIKE
SYNDROME. BLOOD EFFECTS. OTHER SYMPTOMS OF EXPOSURE MAY INCLUDE
DROWSINESS, ALLERGIC RHINITIS, CONJUNCTIVITIS, AND SKIN RASH.
CHRONIC: POSSIBLE TERATOGEN. OVEREXPOSURE MAY CAUSE REPRODUCTIVE
DISORDER(S) BASED ON TESTS WITH LABORATORY ANIMALS. THIS PRODUCT IS
OR CONTAINS A COMPONENT THAT IS NOT CLASSIFIABLE AS TO ITS
CARCINOGENICITY BASED ON ITS (EFTS OF OVEREXP)
Effects of Overexposure:HLTH HAZS: IARC, ACGIH, NTP OR EPA
CLASSIFICATION. TARGET ORGAN(S): LIVER, KIDNEYS, BLOOD. ADDITIONAL
INFORMATION: EXPOSURE TO AND/OR CONSUMPTION OF ALCOHOL MAY INCREASE
TOXIC EFFECTS.

First Aid:IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS
CONSCIOUS. CALL A PHYSICIAN. IN CASE OF SKIN CONTACT, FLUSH WITH
COPIOUS AMOUNTS OF WATER FOR AT LEAST 15 MINUTES. REMOVE
CONTAMINATED CLOTHN G AND SHOES. CALL A PHYSICIAN. IF INHALED,
REMOVE TO FRESH AIR. IF BREATHING BECOMES DIFFICULT, CALL A
PHYSICIAN. IN CASE OF CONTACT WITH EYES, FLUSH WITH COPIOUS AMOUNTS
OF WATER FOR AT LEAST 15 MINU TES. ASSURE ADEQUATE FLUSHING BY
SEPARATING THE EYELIDS WITH FINGERS. CALL A PHYSICIAN.

Extinguishing Media:WATER SPRAY. CARBON DIOXIDE, DRY CHEMICAL POWDER OR
APPROPRIATE FOAM.
Fire Fighting Procedures:WEAR NIOSH APPROVED SELF-CONTAINED BREATHING
APPARATUS AND PROTECTIVE CLOTHING TO PREVENT CONTACT WITH SKIN AND
EYES.
Unusual Fire/Explosion Hazard:EMITS TOXIC FUMES UNDER FIRE CONDITIONS.

Spill Release Procedures:EVACUATE AREA. WEAR NIOSH APPRVD SCBA, RUBBER
BOOTS AND HEAVY RUBBER GLOVES. SWEEP UP, PLACE IN A BAG AND HOLD
FOR WASTE DISPOSAL. AVOID RAISING DUST. VENTILATE AREA AND WASH
SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE.

Handling and Storage Precautions:DO NOT BREATHE DUST. DO NOT GET IN
EYES, ON SKIN, ON CLOTHING. AVOID PRNGD/RPTD EXPOSURE. POSSIBLE
TERATOGEN. REPRODUCTIVE HAZARD. HARMFUL SOLID. IRRITANT. KEEP
TIGHTLY CLOSED. STORE IN A COOL DRY PLA CE. IN CASE OF ACCIDENT/IF
YOU FEEL UNWELL, SEEK MED ADVICE IMMED (SHOW LABEL WHERE POSSIBLE).
Other Precautions:LABEL PRECAUTIONARY STATEMENTS: TOXIC. MAY IMPAIR
FERTILITY. POSS RISK OF HARM TO UNBORN CHILD. HARMFUL BY INHAL, IN
CONT W/SKIN & IF SWALLOWED. IRRITATING TO EYES, RESP SYS & SKIN.
TARGET ORGAN(S): L IVER, KIDNEYS. AVOID EXPOS-OBTAIN SPEC
INSTRUCTION BEFORE USE. WEAR SUITABLE PROT CLTHG, GLOVES & EY
E/FACE PROTECTION.

Respiratory Protection:WEAR APPROPRIATE NIOSH APPROVED RESPIRATOR.
Ventilation:USE ONLY IN A CHEMICAL FUME HOOD.
Protective Gloves:CHEMICAL-RESISTANT GLOVES.
Eye Protection:ANSI APPROVED CHEMICAL WORKERS GOGGLES .
Other Protective Equipment:ANSI APPROVED EYE WASH & DELUGE SHOWER .
OTHER PROTECTIVE CLOTHING.
Work Hygienic Practices:WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health
SOLUBILITY IN H*2O: CHLOROFORM-SOLUBLE. METHANOL-SOLUBLE. TOX INFO:
IPR-GPG LD50:639 MG/KG. ACHTA6 16,316,1970. TARGET ORGAN DATA:
SENSE ORGANS & SPEC SENSES (CONJUNCTIVA IRRIT), (IRITIS), (OTHER
EYE EFTS). BEHAVIORAL (MUSCLE WEAK). LUNGS, THORAX/RESPIRATON
(DYSPNAE). (OTHER INFO)

Melt/Freeze Pt:>183.C, 361.4F
M.P/F.P Text:183-188C
Solubility in Water:SUPDAT
Appearance and Odor:SOLID.

Stability Indicator/Materials to Avoid:YES
Stability Condition to Avoid:PROTECT FROM LIGHT.
Hazardous Decomposition Products:CARBON MONOXIDE, CARBON DIOXIDE,
NITROGEN OXIDES.

Waste Disposal Methods:DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE
SOLVENT AND BURN IN A CHEMICAL INCINERATOR EQUIPPED WITH AN
AFTERBURNER AND SCRUBBER. OBSERVE ALL FEDERAL, STATE AND LOCAL
ENVIRONMENTAL REGULATIONS.

Toxicological Information:ADDNL INFO: EXPOSURE TO AND/OR CONSUMPTION OF
ALCOHOL MAY INCR TOXIC EFTS. RTECS #: VJ7000000. RIFOMYCIN SV,
8-(N-(4-METHYL-1-PIPERAZINYL)FORMIDOYL)-. TOX DATA: ORL-MAN
LDLO:857 MG/KG. JAMAAP 240,2283 ,1978. ORL-RAT LD50:1570 MG/KG.
JJANAX 23,257,1970. IRP-RAT LD50:511 MG/KG. JJANAX 23,257,1970.
SCU-RAT LD50:534 MG/KG. JJANAX 23,242,1970. ORL-MUS LD50:500 MG/KG.
CHDDAT 269,2147,1969. IPR-MUS LD50:4 16 MG/KG. CMTRAG 12,155,1967.
SCU-MUS LD50:621 MG/KG. JJANAX 23,242,1970. IVN-MUS LD50:260 MG/KG.
ACHTA6 16,316,1970. ORL-RBT LD50:2120 MG/KG. ACHTA6 16,316,1970.
(SUPDAT)

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.

Ecological:DATA NOT YET AVAILABLE.

Transport Information:CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION
INFORMATION.

Federal Regulatory Information:EUROPEAN INFO: TOXIC. R 60. MAY IMPAIR
FERTILITY. R 63. POSSIBLE RISK OF HARM TO UNBORN CHILD. R 20/21/22.
HARMFUL BY INHAL, IN CONT W/SKIN & IF SWALLOWED. R 36/37/38.
IRRITATING TO EYES, RESP SYS & S KIN. S 53. AVOID EXPO-OBTAIN SPEC
INSTRUCTIONS BEFORE REUSE. S 45. IN CASE OF ACCIDENT/IF YOU FEEL
UNWELL, SEEK MED ADVICE IMMED (SHOW LABEL WHERE POSSIBLE). S
36/37/39. WEAR SUITABLE PROT CLTHG, GLOV ES & EYE/FACE PROT. S 22.
DO NOT BREATHE DUST. REVIEWS, STDS, & REGS. OEL=MAK. IARC CANCER
REVIEW:AN IMAL LIMITED EVIDENCE. IMEMDT 24,243,1980. IARC CANCER
REVIEW: HUMAN NO ADEQ DATA. (OTHER INFO)